The present study is aimed to investigate the clinical and pathologic features of GI
Iymphomas and the immunocytochemical characteristics, using 71 cases of primary GI
Iymphomas examined at the Department of Pathology, Yonsei university College of
Medicine, Youngdong Serverance Hospital and Yonsei University Wonju college of
Medicine from January, 1976 to December, 1985.
Results obtained were as follows:
1) Sixty eight cases were Non-Hodgkin's Iymphoma and 3 Hodgkin's Iymphoma.
Sugical resection was done in 55 patients anti surgical biopsy in 13.
2) The primary sites of the tumors were stomach, small intestine, ileocecal area and
large intestine in a descending order of frequency.
3) The mean age at the time of diagnosis was 45 years. The tumor of the small
intestine was generally detected in the younger age and that of the large intestine in
the oldsγ age. The overall male to female ratio was 1.9:1
4) Abdominal pain was the most common presenting symptom irrespective of the sites
of the tumor. Duration of the symptoms were evenly distributed from hours to 12
months.
5) The sire of the tumors was less than 10 cm in the largest dimension in most of
the cases (79.3%). The gross types of the GI Iymphomas were ulcerative (27.6%),
polypoid (20.7%), multinodulated (17.2%) and diffuse thickening. The rate of Iymph node
involvement was 44.4% in tumors confined to the serosa, while 82.6% in tumors with
serosal penetrations.
6) Classification of 68 cases of Non-Hodgkin's Iymphoma according to Working
Formulation revealed 50 cases of intermediate grade, 13 cases of high grade and 5 cases
of low grade. According to Rappaport classification, all were diffuse types, among which
diffuse histiocytic type was the most common. According to Lukes-Collins classification,
60 cases were B cell types, 4 cases genuine histiocytic types and 3 cases T cell types.
Most of the gastric and intestinal Iymphomas belonged to the follicular center cell
(small and large cleaved, large cleaved) types.
7) Immunoperoxidase stains were done in 55 cases of malignant Iymphomas. Thirty
(65.9%) of 47 B cell Iymphomas revealed a positivity for B cell markers. Twenty three
(48.9%) of them showed a monoclonality, in which kappa/IgG pattern was most
frequently demonstrated. Four cases of true histiocytic Iymphomas were positive for
alpha-1-antichymotrypsin and Iysozyme, the former of which was seemed to be a more
sensitive marker for histiocytic differentiation. An attempt was made to evaluate the
significance of the degree of reactive histiocytic infiltrates within the Iymphoma in
relation to the prognosis, but correlation could not be made because of the limited cases.
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